Neoplasm localization with radionuclides
Identifieur interne : 003880 ( Main/Exploration ); précédent : 003879; suivant : 003881Neoplasm localization with radionuclides
Auteurs : Vincent Lopez-Majano [États-Unis] ; Jorge Alvarez-Cervera [Mexique]Source :
- European Journal of Nuclear Medicine [ 0340-6997 ] ; 1979-10-01.
English descriptors
- Teeft :
- Active transport, Annual meeting, Antibiotic, Benign lesions, Bleomycin, Bloodbrain barrier, Bone lesions, Brain diseases, Brain lesions, Brain neoplasms, Brain scanning, Brain scintigraphy, Brain tumors, Breast cancer, Breast tumors, Bronchogenic carcinoma, Cancer inst, Carcinoma, Cervera, Chir, Citrate, Citrate imaging, Cold lesions, Diagnostic agent, Different forms, Differential diagnosis, Diseased area, Distant metastases, Energy agency, False positives, Gallium, Gallium scanning, Gallium scintigraphy, Hepatoma, Human fibrinogen, Imaging, Inflammatory lesions, Lesion, Liver scintigraphy, Localization, Lung cancer, Lung carcinoma, Lymphoma, Malignant, Malignant melanoma, Malignant tumors, Medical radioisotope scintigraphy, Melanoma, Mercure, Mercure radioactif, Mercure radioactifs, Metabolism, Metastasis, Miami beach, Monod, Neoplasm, Neoplasm localization, Neoplastic, Neoplastic cells, Neoplastic cells affinity, Neoplastic disease, Neoplastic lesions, Neoplastic tissue, Nucl, Nuclear medicine, Osteoblastic activity, Other agents, Other antibiotics, Other authors, Other type, Parenchymal destruction, Peripheral lung tumors, Pertechnetate, Polyphosphate, Positive results, Positive scans, Preferential uptake, Pulmonaires, Radioisotope, Radioisotope scanning, Radiology, Radionuclide, Radionuclide studies, Radionuclides, Radionuclides table, Radiopharmaceutical, Radiopharmaceutical works, Raynaud, Rymer, Sarcoma, Scanning, Scintigraphie pulmonaire, Scintigraphies, Scintigraphies pulmonaires, Scintigraphy, Soft tissue tumors, Tetracycline, Tumeurs malignes, Tumor, Tumor antibodies, Tumor imaging, Tumor localization, Tumor scanning, Tumor scanning agent, Uptake.
Abstract
Abstract: Tumor scintigraphic localization of neoplasms can be done in two ways: indirectly and directly. The first method shows alternations of the normal structure of the organ, such as “cold lesions” in liver and thyroid. Abnormalities in function as increased permeability of the blood barrier results from abnormal deposition of the radionuclide in the brain scintigram of a patient with neoplasm. Increased focal areas of uptake of bone-seeking radionuclides are very characteristic of metastases. The direct methods depend on preferential uptake of the radionuclide by the neoplastic tissue resulting from altered metabolism (e.g. Se-75). Other agents such as Gallium-67 have affinity for neoplasms. Another approach is to use antineoplastic agents and radioactive antibodies which will localize in the tumor. At this stage the most useful neoplasm seeking agents are Gallium-67 citrate and 111In-Bleomycin, even though infections can give false positives. The possibility should be considered of enhancing the uptake of radionuclides by neoplastic cells using increased O2 concentration.
Url:
DOI: 10.1007/BF00263297
Affiliations:
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Harrison Street, 60612, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Alvarez Cervera, Jorge" sort="Alvarez Cervera, Jorge" uniqKey="Alvarez Cervera J" first="Jorge" last="Alvarez-Cervera">Jorge Alvarez-Cervera</name><affiliation wicri:level="1"><country xml:lang="fr">Mexique</country><wicri:regionArea>Hospital 20 de Noviembre, Mexico, D.F.</wicri:regionArea><wicri:noRegion>D.F.</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Nuclear Medicine</title><title level="j" type="abbrev">Eur J Nucl Med</title><idno type="ISSN">0340-6997</idno><idno type="eISSN">1619-7089</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1979-10-01">1979-10-01</date><biblScope unit="volume">4</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="313">313</biblScope><biblScope unit="page" to="324">324</biblScope></imprint><idno type="ISSN">0340-6997</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-6997</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Active transport</term><term>Annual meeting</term><term>Antibiotic</term><term>Benign lesions</term><term>Bleomycin</term><term>Bloodbrain barrier</term><term>Bone lesions</term><term>Brain diseases</term><term>Brain lesions</term><term>Brain neoplasms</term><term>Brain scanning</term><term>Brain scintigraphy</term><term>Brain tumors</term><term>Breast cancer</term><term>Breast tumors</term><term>Bronchogenic carcinoma</term><term>Cancer inst</term><term>Carcinoma</term><term>Cervera</term><term>Chir</term><term>Citrate</term><term>Citrate imaging</term><term>Cold lesions</term><term>Diagnostic agent</term><term>Different forms</term><term>Differential diagnosis</term><term>Diseased area</term><term>Distant metastases</term><term>Energy agency</term><term>False positives</term><term>Gallium</term><term>Gallium scanning</term><term>Gallium scintigraphy</term><term>Hepatoma</term><term>Human fibrinogen</term><term>Imaging</term><term>Inflammatory lesions</term><term>Lesion</term><term>Liver scintigraphy</term><term>Localization</term><term>Lung cancer</term><term>Lung carcinoma</term><term>Lymphoma</term><term>Malignant</term><term>Malignant melanoma</term><term>Malignant tumors</term><term>Medical radioisotope scintigraphy</term><term>Melanoma</term><term>Mercure</term><term>Mercure radioactif</term><term>Mercure radioactifs</term><term>Metabolism</term><term>Metastasis</term><term>Miami beach</term><term>Monod</term><term>Neoplasm</term><term>Neoplasm localization</term><term>Neoplastic</term><term>Neoplastic cells</term><term>Neoplastic cells affinity</term><term>Neoplastic disease</term><term>Neoplastic lesions</term><term>Neoplastic tissue</term><term>Nucl</term><term>Nuclear medicine</term><term>Osteoblastic activity</term><term>Other agents</term><term>Other antibiotics</term><term>Other authors</term><term>Other type</term><term>Parenchymal destruction</term><term>Peripheral lung tumors</term><term>Pertechnetate</term><term>Polyphosphate</term><term>Positive results</term><term>Positive scans</term><term>Preferential uptake</term><term>Pulmonaires</term><term>Radioisotope</term><term>Radioisotope scanning</term><term>Radiology</term><term>Radionuclide</term><term>Radionuclide studies</term><term>Radionuclides</term><term>Radionuclides table</term><term>Radiopharmaceutical</term><term>Radiopharmaceutical works</term><term>Raynaud</term><term>Rymer</term><term>Sarcoma</term><term>Scanning</term><term>Scintigraphie pulmonaire</term><term>Scintigraphies</term><term>Scintigraphies pulmonaires</term><term>Scintigraphy</term><term>Soft tissue tumors</term><term>Tetracycline</term><term>Tumeurs malignes</term><term>Tumor</term><term>Tumor antibodies</term><term>Tumor imaging</term><term>Tumor localization</term><term>Tumor scanning</term><term>Tumor scanning agent</term><term>Uptake</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Tumor scintigraphic localization of neoplasms can be done in two ways: indirectly and directly. The first method shows alternations of the normal structure of the organ, such as “cold lesions” in liver and thyroid. Abnormalities in function as increased permeability of the blood barrier results from abnormal deposition of the radionuclide in the brain scintigram of a patient with neoplasm. Increased focal areas of uptake of bone-seeking radionuclides are very characteristic of metastases. The direct methods depend on preferential uptake of the radionuclide by the neoplastic tissue resulting from altered metabolism (e.g. Se-75). Other agents such as Gallium-67 have affinity for neoplasms. Another approach is to use antineoplastic agents and radioactive antibodies which will localize in the tumor. At this stage the most useful neoplasm seeking agents are Gallium-67 citrate and 111In-Bleomycin, even though infections can give false positives. The possibility should be considered of enhancing the uptake of radionuclides by neoplastic cells using increased O2 concentration.</div></front></TEI><affiliations><list><country><li>Mexique</li><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Lopez Majano, Vincent" sort="Lopez Majano, Vincent" uniqKey="Lopez Majano V" first="Vincent" last="Lopez-Majano">Vincent Lopez-Majano</name></region></country><country name="Mexique"><noRegion><name sortKey="Alvarez Cervera, Jorge" sort="Alvarez Cervera, Jorge" uniqKey="Alvarez Cervera J" first="Jorge" last="Alvarez-Cervera">Jorge Alvarez-Cervera</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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